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Home - Products - GPCR/G Protein - Chemokine Receptor - MLN 3897

MLN 3897

CAS No. 1010731-97-1

MLN 3897( AVE 9897 )

Catalog No. M10069 CAS No. 1010731-97-1

MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 1039 Get Quote
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Biological Information

  • Product Name
    MLN 3897
  • Note
    Research use only, not for human use.
  • Brief Description
    MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays.
  • Description
    MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5; inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-fos signaling, inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-Fos signaling; demonstrates potential for the treatment of multiple sclerosis and rheumatoid arthritis.Multiple Sclerosis Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AVE 9897
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    Multiple Sclerosis

Chemical Information

  • CAS Number
    1010731-97-1
  • Formula Weight
    535.125
  • Molecular Formula
    C32H39ClN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O[C@@]1(C2=CC=C(Cl)C=C2)C(C)(C)CN(CC/C=C3C(C=CCN4)=C4COC5=CC=C(C(C)(O)C)C=C\35)CC1
  • Chemical Name
    (S,E)-4-(4-chlorophenyl)-1-(3-(7-(2-hydroxypropan-2-yl)-2,11-dihydrobenzo[6,7]oxepino[3,4-b]pyridin-5(1H)-ylidene)propyl)-3,3-dimethylpiperidin-4-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38. 2. Vallet S, et al. Blood. 2007 Nov 15;110(10):3744-52. 3. Lu C, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):562-8. 4. Vergunst CE, et al. Arthritis Rheum. 2009 Dec;60(12):3572-81.
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